Oxaprozin

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Oxaprozin, drug used for relief of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, gout, and tendinitis. Oxaprozin blocks the production of chemicals called prostaglandins, which may trigger pain and inflammation.

This drug is available by prescription only and comes in 600-mg caplets that are taken orally. The typical adult dosage is 1200 mg per day determined individually on the basis of weight and health. Pain is usually relieved after a single dose, but reduction of inflammation may require regular doses for several days. One to two weeks of continual usage determines the general effectiveness of the drug, although the full effect may not be apparent during the first six weeks of regular use.

Oxaprozin should be taken with a full glass of water or milk, with meals, or with a prescribed antacid. To avoid adverse side effects, the lowest effective daily dose should be taken. Persons who have had a previous allergic reaction to oxaprozin or to any other nonsteroidal anti-inflammatory drug, such as aspirin, should not take this drug. It should be avoided by pregnant or breast-feeding women, and by persons with bleeding or blood cell disorders, or a severe impairment of kidney function. It should be used with caution by persons with reduced liver or kidney function. The safety and effectiveness of this drug for children under the age of 12 have not been established. Small doses are advisable for persons over the age of 60 until tolerance is determined. Driving and other risk-related activities should be restricted if drowsiness or dizziness occurs.

Possible side effects of oxaprozin may include altered or blurred vision, constipation, depression, diarrhea, dizziness, headache, hives, indigestion, itching, mouth sores, nausea, ringing in the ears, skin rash, increased skin sensitivity to sunlight, sleep disturbances, and vomiting. Rare but serious side effects include kidney damage and gastrointestinal pain, ulceration, and bleeding.

Drinking alcoholic beverages with this drug may increase the risk of stomach ulceration or bleeding. Oxaprozin may interact adversely with other drugs including acetaminophen; anticoagulants; aspirin; beta blockers; diuretics such as hydrochlorothiazide and furosemide; enoxaparin; indomethacin; lithium; methotrexate; sulfinpyrazone; valproic acid; and warfarin.

Brand Name:Daypro

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