Diseases of the Endocrine System
. Endocrine disorders are classified in two ways: disturbances in the production of hormones, and the inability of tissues to respond to hormones. The first type, called production disorders, are divided into hypofunction (insufficient activity) and hyperfunction (excess activity). Hypofunction disorders can have a variety of causes, including malformations in the gland itself. Sometimes one of the enzymes essential for hormone production is missing, or the hormone produced is abnormal. More commonly, hypofunction is caused by disease or injury. Tuberculosis can appear in the adrenal glands, autoimmune diseases can affect the thyroid, and treatments for cancer—such as radiation therapy and chemotherapy—can damage any of the endocrine organs. Hypofunction can also result when target tissue is unable to respond to hormones. In many cases, the cause of a hypofunction disorder is unknown. Hyperfunction can be caused by glandular tumors that secrete hormone without responding to feedback c