Aspirin and Vitamin C

Aspirin and Vitamin C
by Dr. Leo Galland

Aspirin (acetylsalicylic acid) has been around for over a hundred years and can be a useful drug for treating pain. Millions of people take low dose aspirin every day in an effort to prevent heart attacks or strokes. But aspirin can erode the lining of the stomach or intestines, causing internal bleeding, even at low doses.

Research on Aspirin and Vitamin C

Research studies done in Germany demonstrate that aspirin interferes with absorption of vitamin C and regular use of aspirin can deplete the gastrointestinal lining of vitamin C.

German researchers have shown that taking vitamin C along with aspirin can decrease the amount of stomach damage that aspirin produces in healthy humans and in patients with inflammation of the stomach caused by infection with Helicobacter pylori, a bacterium that causes ulcers.

No dietary supplement is guaranteed to prevent aspirin-induced gastrointestinal damage.

If you are taking aspirin, ask your doctor whether vitamin C might be good to take along with it.

REFERENCES AND ABSTRACTS

Eur J Pharmacol. 2004 Dec 15;506(2):169-77.Effect of vitamin C-releasing acetylsalicylic acid on gastric mucosal damage before and after Helicobacter pylori eradication therapy. Konturek PC, Kania J, Gessner U, Konturek SJ, Hahn EG, Konturek JW. First Department of Medicine, University Erlangen-Nuremberg, Germany.

Aspirin

Aspirin, synthetic chemical compound, acetylsalicylic acid. It is made from salicylic acid, found in the bark of the willow tree, which was used by the ancient Greeks and Native Americans, among others, to counter fever and pain. Salicylic acid is bitter, however, and irritates the stomach. The German chemist Felix Hoffman synthesized the acetyl derivative of salicylic acid in 1893 in response to the urging of his father, who took salicylic acid for rheumatism. Aspirin is currently the first-choice drug for fever, mild to moderate pain, and inflammation due to arthritis or injury. It is a more effective analgesic than codeine. Aspirin causes insignificant gastrointestinal bleeding that can over time, however, cause iron deficiency; gastric ulcers may also occur with long-term use. Complications can be avoided by using enteric-coated aspirin, which does not dissolve until reaching the intestine. Aspirin should not be given to children who have chicken pox or influenza, because it increases the risk of contracting the rare and frequently fatal Reye's syndrome, a disease of the brain and some abdominal organs.

Aspirin is thought to act by interfering with synthesis of prostaglandins, which are implicated in inflammation and fever. Studies of aspirin's anticlotting activities suggest that half an aspirin tablet per day may reduce the risk of heart attack and stroke in some persons.