Nabumetone
Nabumetone, nonsteroidal anti-inflammatory drug used for relief of pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Nabumetone blocks the production of certain chemicals in the body called prostaglandins that may trigger pain and inflammation.
This drug is available by prescription only. It comes in 500-mg and 700-mg tablets, taken orally. The typical, initial adult dosage is 1000 mg per day. This dosage may be increased as needed and tolerated to 1500 to 2000 mg per day, taken once a day or in divided doses. Relief of symptoms may be felt within one hour, but it may take up to two weeks to feel the full effect of the drug.
Nabumetone should be taken on a regular schedule, without missing doses. It should be taken with food to increase absorption of the drug and to prevent stomach irritation. To minimize adverse side effects, the lowest effective daily dose should be used. Nabumetone should not be used by persons who have had a previous allergic reaction to this drug or an asthmatic reaction to aspirin; pregnant or breast-feeding women; or persons with peptic ulcers or any form of gastrointestinal ulceration or bleeding, bleeding or blood cell disorders, liver disease, or severe impairment of kidney function. It should be used with caution by persons with reduced liver or kidney function and persons taking drugs that reduce blood clotting. The safety and efficacy of this drug for children under the age of 12 have not been established. Reduced dosages are advised for persons over the age of 60 until their tolerance of nabumetone has been determined. Driving or other risk-related activities should be restricted if drowsiness, dizziness, or impaired vision occurs with use of this drug.
Certain mild side effects may occur with nabumetone that should disappear as the body adapts to the drug. These include bloating, constipation, diarrhea, difficulty sleeping, dizziness, drowsiness, headache, heartburn, indigestion, lightheadedness, loss of appetite, nausea, nervousness, soreness of the mouth, sweating, or vomiting. More serious but uncommon side effects include activation of peptic ulcer disease or ulcerative colitis, asthma or difficulty breathing, bleeding in the stomach or duodenum, blurred vision, impairment of normal blood clotting, and liver or kidney damage. This drug may also cause increased sensitivity to sunlight.
Nabumetone may interact adversely with alcoholic beverages and with certain other drugs including anticoagulants (blood thinners) such as warfarin; aspirin, other salicylates, and other anti-inflammatory drugs; beta blockers; diuretics; and probenecid.
This drug is available by prescription only. It comes in 500-mg and 700-mg tablets, taken orally. The typical, initial adult dosage is 1000 mg per day. This dosage may be increased as needed and tolerated to 1500 to 2000 mg per day, taken once a day or in divided doses. Relief of symptoms may be felt within one hour, but it may take up to two weeks to feel the full effect of the drug.
Nabumetone should be taken on a regular schedule, without missing doses. It should be taken with food to increase absorption of the drug and to prevent stomach irritation. To minimize adverse side effects, the lowest effective daily dose should be used. Nabumetone should not be used by persons who have had a previous allergic reaction to this drug or an asthmatic reaction to aspirin; pregnant or breast-feeding women; or persons with peptic ulcers or any form of gastrointestinal ulceration or bleeding, bleeding or blood cell disorders, liver disease, or severe impairment of kidney function. It should be used with caution by persons with reduced liver or kidney function and persons taking drugs that reduce blood clotting. The safety and efficacy of this drug for children under the age of 12 have not been established. Reduced dosages are advised for persons over the age of 60 until their tolerance of nabumetone has been determined. Driving or other risk-related activities should be restricted if drowsiness, dizziness, or impaired vision occurs with use of this drug.
Certain mild side effects may occur with nabumetone that should disappear as the body adapts to the drug. These include bloating, constipation, diarrhea, difficulty sleeping, dizziness, drowsiness, headache, heartburn, indigestion, lightheadedness, loss of appetite, nausea, nervousness, soreness of the mouth, sweating, or vomiting. More serious but uncommon side effects include activation of peptic ulcer disease or ulcerative colitis, asthma or difficulty breathing, bleeding in the stomach or duodenum, blurred vision, impairment of normal blood clotting, and liver or kidney damage. This drug may also cause increased sensitivity to sunlight.
Nabumetone may interact adversely with alcoholic beverages and with certain other drugs including anticoagulants (blood thinners) such as warfarin; aspirin, other salicylates, and other anti-inflammatory drugs; beta blockers; diuretics; and probenecid.
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